4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸

中文名	贝托斯汀
英文名	Bepotastine
别名	苯钾碱贝托斯汀贝托司汀 S)-贝托斯汀 4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸 (S)-4-(4-((4-氯苯基)(吡啶-2-基)甲氧基)哌啶-1-基)丁酸 (+)-(S)-4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸
英文别名	Betotastine BEPOTASTINE Bepotastine (+)-BEPOTASTINE betotastine besilate -4-(4-((4-Chlorophenyl) 4-[(S)-(4-chlorophenyl)-2-pyridinylMethoxy]- 4-((4-Chlorophenyl)-2-pyridinylmethoxy)-1-piperidinebutanoic acid 4-(4-[(1s)(4-chlorophenyl)-2-pyridylmethoxy]piperidyl)butanoic acid 4-(4-[(1S)(4-CHLOROPHENYL)-2-PYRIDYLMETHOXY]PIPERIDYL)BUTANOIC ACID 4-[4-[(4-Chlorophenyl)pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]- 4-{4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid 4-{4-[(S)-(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid (+)-(S)-4-[4-[1-(4-chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid
CAS	125602-71-3 190786-43-7
EINECS	200-258-5
化学式	C21H25ClN2O3
分子量	388.89
InChI	InChI=1/C21H25ClN2O3/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26)/t21-/m0/s1
密度	1.26
熔点	56 - 58°C
沸点	546.8±50.0 °C(Predicted)
闪点	284.5°C
蒸汽压	8.63E-13mmHg at 25°C
溶解度	DMSO (微溶) 、甲醇 (微溶)
折射率	1.605
酸度系数	4.44±0.10(Predicted)
存储条件	-20°C Freezer, Under inert atmosphere
外观	固体
颜色	White to Pale Beige
体外研究	Bepotastine possesses additional anti-allergic activity including stabilization of mast cell function, inhibition of eosinophilic infiltration, inhibition of IL-5 production, and inhibition of leukotriene B4 (LTB4) and LTD4 activity. Bepotastine significantly inhibits antigen-induced stimulation of IL-5 production in human peripheral blood mononuclear cells (PBMCs) at concentrations of 10-100 μM and the effect is enhanced when the PBMCs are pre-incubated with Bepotastine. Leukotriene B4 increased Ca2+ concentration in cultured neutrophils, which is suppressed by Bepotastine besilate (1-100 μM). Leukotriene B4 increased Ca2+ concentration in cultured dorsal root ganglion neurons, which is also suppressed by Bepotastine besilate (100 μM).
体内研究	Bepotastine besilate (10 mg/kg) inhibits scratching induced by an intradermal injection of histamine (100 nmol/site), but not serotonin (100 nmol/site). Bepotastine besilate (1-10 mg/kg, oral) dose-dependently suppresses scratching induced by substance P (100 nmol/site) and leukotriene B4 (0.03 nmol/site). Bepotastine in vivo dose-dependently inhibits the acceleration of histamine-induced vascular permeability and inhibits homologous passive cutaneous anaphylaxis in guinea pig studies. In mouse models of itching, oral Bepotastine inhibits the frequency and duration of scratching behavior.

4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.571 ml	12.857 ml	25.714 ml
5 mM	0.514 ml	2.571 ml	5.143 ml
10 mM	0.257 ml	1.286 ml	2.571 ml
5 mM	0.051 ml	0.257 ml	0.514 ml

最后更新：2024-01-02 23:10:35

4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸 - 简介

贝托斯汀，也称为氢氧化苯甲酸酯，是一种有机化合物。

性质：贝托斯汀为无色液体，具有芳香气味。它的密度较低，可溶于多种有机溶剂，如醇类和醚类。

制法：贝托斯汀的制备可以通过苯甲酸和乙醇反应而成。即在碱的催化下，苯甲酸与乙醇反应生成乙酸苯酯，再在碱的作用下水解生成贝托斯汀。

安全信息：贝托斯汀的接触应避免皮肤、眼睛和呼吸道。使用时应佩戴适当的防护措施，如手套和化学护目镜。如不慎接触，应立即用大量清水冲洗。存放时应远离火源和氧化剂，确保通风良好。

最后更新：2024-04-09 18:58:34

湖北扬信医药科技有限公司

产品名: 贝托斯汀单体询盘
CAS: 125602-71-3
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产品名: 贝托司汀去供应商网站查看询盘
CAS: 125602-71-3
产地: 中国上海
包装: 100mg
规格: 98%
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产品描述: 中文名：贝托司汀英文名:Bepotastine CAS:125602-71-3 规格:98% 产地:中国上海

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现货供应

产品名: (S)-4-(4-((4-氯苯基)(吡啶-2-基)甲氧基)哌啶-1-基)丁酸去供应商网站查看询盘
CAS: 125602-71-3
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